Since the first pioneering studies on small deuterated peptides dating more than 20 years
ago, 1H detection has evolved into the most efficient approach for investigation of …

With the development of NMR methodology and technology during the past decades, solid-
state NMR (ssNMR) has become a particularly important tool for investigating structure and …

The protein kinase PINK 1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65,
and phosphoUb activates the E3 ligase Parkin allosterically. Here, we show that PINK 1 can …

Nuclear magnetic resonance (NMR) is widely used across many fields of science because
of the rich data it produces, and some of the most valuable data come from studies of …

The accuracy inherent in the measurement of interproton distances in small molecules by
nuclear Overhauser enhancement (NOE) and rotational Overhauser enhancement (ROE) …

The nuclear Overhauser enhancement or effect (NOE) is the most important measure in
liquid-state NMR with macromolecules. Thus, the NOE is the subject of numerous reviews …

Recent methodological advances in solution NMR allow the determination of multi-state
protein structures and provide insights into structurally and dynamically correlated protein …

Structural disorder of functional proteins under physiological conditions is widespread within
eukaryotic proteomes. The lack of stable tertiary and secondary structure offers a variety of …

Proteins composed of multiple domains allow for structural heterogeneity and interdomain
dynamics that may be vital for function. Intradomain structures and dynamics can influence …

The biological activities and pharmacological properties of peptides and peptide mimetics
are determined by their conformational states. Therefore, a detailed understanding of the …