Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Q Ru, Y Li, L Chen, Y Wu, J Min, F Wang - Signal transduction and …, 2024 - nature.com
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship

J Mesinovic, A Zengin, B De Courten… - … syndrome and obesity …, 2019 - Taylor & Francis
The incidence and prevalence of metabolic and musculoskeletal diseases are increasing.
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance, inflammation …

The continuum of aging and age-related diseases: common mechanisms but different rates

C Franceschi, P Garagnani, C Morsiani, M Conte… - Frontiers in …, 2018 - frontiersin.org
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …

Nutrition management in older adults with diabetes: a review on the importance of shifting prevention strategies from metabolic syndrome to frailty

Y Tamura, T Omura, K Toyoshima, A Araki - Nutrients, 2020 - mdpi.com
The increasing prevalence of older adults with diabetes has become a major social burden.
Diabetes, frailty, and cognitive dysfunction are closely related to the mechanisms of aging …

Effects of IGF‐1 isoforms on muscle growth and sarcopenia

F Ascenzi, L Barberi, G Dobrowolny… - Aging cell, 2019 - Wiley Online Library
The decline in skeletal muscle mass and strength occurring in aging, referred as sarcopenia,
is the result of many factors including an imbalance between protein synthesis and …

Biological aspects of selected myokines in skeletal muscle: focus on aging

R Mancinelli, F Checcaglini, F Coscia… - International journal of …, 2021 - mdpi.com
In the last decade, clear evidence has emerged that the cellular components of skeletal
muscle are important sites for the release of proteins and peptides called “myokines” …

The association between sarcopenia and diabetes: from pathophysiology mechanism to therapeutic strategy

H Chen, X Huang, M Dong, S Wen… - … Syndrome and Obesity, 2023 - Taylor & Francis
Diabetes and sarcopenia are emerging as serious public health issues. Sarcopenia, an age-
related disorder characterized by loss of skeletal muscle mass and function, is recognized …

The KEAP1-NRF2 system in healthy aging and longevity

D Matsumaru, H Motohashi - Antioxidants, 2021 - mdpi.com
Aging is inevitable, but the inherently and genetically programmed aging process is
markedly influenced by environmental factors. All organisms are constantly exposed to …

Sarcopenia and Cognitive decline in older adults: targeting the muscle–brain Axis

B Arosio, R Calvani, E Ferri, HJ Coelho-Junior… - Nutrients, 2023 - mdpi.com
Declines in physical performance and cognition are commonly observed in older adults. The
geroscience paradigm posits that a set of processes and pathways shared among age …

Muscular atrophy and sarcopenia in the elderly: is there a role for creatine supplementation?

E Dolan, GG Artioli, RMR Pereira, B Gualano - Biomolecules, 2019 - mdpi.com
Sarcopenia is characterized by a loss of muscle mass, quality, and function, and negatively
impacts health, functionality, and quality of life for numerous populations, particularly older …