Abstract Background/Aims: On behalf of the Drug and Therapeutics, and Ethics Committees
of the Pediatric Endocrine Society, we sought to update the guidelines published in 2003 on …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Despite the high prevalence of performance-enhancing drug (PED) use, media attention has
focused almost entirely on PED use by elite athletes to illicitly gain a competitive advantage …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Mutations in growth signaling pathways extend life span, as well as protect against age-
dependent DNA damage in yeast and decrease insulin resistance and cancer in mice. To …

Increased life expectancy combined with the aging baby boomer generation has resulted in
an unprecedented global expansion of the elderly population. The growing population of …

Although for most children the process of atherosclerosis is subclinical, dramatically
accelerated atherosclerosis occurs in some pediatric disease states, with clinical coronary …

Adult growth hormone deficiency (GHD) is characterized by metabolic abnormalities
associated with visceral obesity, impaired quality of life, and increased mortality. Patients …

This contribution will address the effect of aging on skin functions, with a particular focus on
skin permeability, wound healing, angiogenesis, lipogenesis, sweat production, immune …

Intrathecal administration of opioids is a very efficient tool in the long-term control of
intractable nonmalignant pain. However, despite the well known role of opioids in endocrine …