Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Alu elements are highly abundant primate-specific short interspersed nuclear elements that
account for~ 10% of the human genome. Due to their preferential location in gene-rich …

With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …

The progression of kidney disease varies among individuals, but a general methodology to
quantify disease timelines is lacking. Particularly challenging is the task of determining the …

RNA modifications are widespread throughout the mammalian transcriptome and play
pivotal roles in regulating various cellular processes. These modifications are strongly linked …

Aberrant RNA editing has emerged as a pivotal factor in the pathogenesis of hepatocellular
carcinoma (HCC), but the impact of RNA co-editing within HCC remains underexplored. We …

Abstract The 14th International Podocyte Conference took place in Philadelphia, USA, from
May 23rd to 26th, 2023. It commenced with an early-career researchers' meeting on May …

The field of nephrology has recently directed a considerable amount of attention towards the
stimulator of interferon genes (STING) molecule since it appears to be a potent driver of …

It is well established that sevoflurane exposure leads to widespread neuronal cell death in
the developing brain. Adenosine deaminase acting on RNA-1 (ADAR1) dependent …

Notwithstanding remaining controversies and uncertainties, promising genomically precise
therapies targeted at APOL1 mRNA using antisense oligonucleotides (ASO), inhibitors of …