Cadherin signaling in cancer: its functions and role as a therapeutic target

W Yu, L Yang, T Li, Y Zhang - Frontiers in oncology, 2019 - frontiersin.org
Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-
dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and …

Dendritic spines: the locus of structural and functional plasticity

C Sala, M Segal - Physiological reviews, 2014 - journals.physiology.org
The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

Functions of p38 MAP kinases in the central nervous system

PR Asih, E Prikas, K Stefanoska, ARP Tan… - Frontiers in molecular …, 2020 - frontiersin.org
Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

Beyond E-cadherin: roles of other cadherin superfamily members in cancer

F Van Roy - Nature Reviews Cancer, 2014 - nature.com
Abstract Loss of cadherin 1 (CDH1; also known as epithelial cadherin (E-cadherin)) is used
for the diagnosis and prognosis of epithelial cancers. However, it should not be ignored that …

Involvement of members of the cadherin superfamily in cancer

G Berx, F Van Roy - Cold Spring Harbor perspectives in …, 2009 - cshperspectives.cshlp.org
We review the role of cadherins and cadherin-related proteins in human cancer. Cellular
and animal models for human cancer are also dealt with whenever appropriate. E-cadherin …

[HTML][HTML] Unraveling mechanisms of homeostatic synaptic plasticity

K Pozo, Y Goda - Neuron, 2010 - cell.com
Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset
excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings …

Protocadherins at the crossroad of signaling pathways

A Pancho, T Aerts, MD Mitsogiannis… - Frontiers in Molecular …, 2020 - frontiersin.org
Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …

Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection

SW Flavell, TK Kim, JM Gray, DA Harmin, M Hemberg… - Neuron, 2008 - cell.com
Although many transcription factors are known to control important aspects of neural
development, the genome-wide programs that are directly regulated by these factors are not …

Cadherins in brain morphogenesis and wiring

S Hirano, M Takeichi - Physiological reviews, 2012 - journals.physiology.org
Cadherins are Ca2+-dependent cell-cell adhesion molecules that play critical roles in
animal morphogenesis. Various cadherin-related molecules have also been identified …

[HTML][HTML] Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

NP Tsai, JR Wilkerson, W Guo, MA Maksimova… - Cell, 2012 - cell.com
The activity-dependent transcription factor myocyte enhancer factor 2 (MEF2) induces
excitatory synapse elimination in mouse neurons, which requires fragile X mental …