Bladder cancer is a global health issue with sex differences in incidence and prognosis.
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …

Importance Bladder cancer is a common malignancy in women and is the fourth most
common malignancy in men. Bladder cancer ranges from unaggressive and usually …

The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized
by large biological heterogeneity with variable clinical outcomes. Here, we perform an …

Background Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with
heterogeneous clinical outcomes. Several molecular classifications have been proposed …

The extent of somatic mutation and clonal selection in the human bladder remains unknown.
We sequenced 2097 bladder microbiopsies from 20 individuals using targeted (n= 1914 …

Non-muscle-invasive bladder cancer (NMIBC) is an early-stage cancer without invasion into
the detrusor muscle layer. Transurethral resection of bladder tumour (TURBT) is a diagnostic …

The human papillomavirus (HPV) family includes more than 170 different types of virus that
infect stratified epithelium. High-risk HPV is well established as the primary cause of cervical …

Neoadjuvant chemotherapy (NAC) prior to surgery and immune checkpoint therapy (ICT)
have revolutionized bladder cancer management. However, stratification of patients that …

Lysine-specific demethylase 6A (KDM6A), also named UTX, is frequently mutated in bladder
cancer (BCa). Although known as a tumor suppressor, KDM6A's therapeutic potential in the …

Background Previous molecular subtyping for bladder carcinoma (BLCA) involved< 450
samples, with diverse classifications. Objective To identify molecular subtypes by curating a …