[HTML][HTML] Neuropathology of Alzheimer's disease

JA Trejo-Lopez, AT Yachnis, S Prokop - Neurotherapeutics, 2022 - Elsevier
The key pathological hallmarks—extracellular plaques and intracellular neurofibrillary
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …

Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways

SM Greenberg, BJ Bacskai… - Nature Reviews …, 2020 - nature.com
The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy study

A Charidimou, G Boulouis, MP Frosch… - The Lancet …, 2022 - thelancet.com
Background Cerebral amyloid angiopathy (CAA) is an age-related small vessel disease,
characterised pathologically by progressive deposition of amyloid β in the cerebrovascular …

Progression of cerebral amyloid angiopathy: a pathophysiological framework

EA Koemans, JP Chhatwal, SJ van Veluw… - The Lancet …, 2023 - thelancet.com
Cerebral amyloid angiopathy, which is defined by cerebrovascular deposition of amyloid β,
is a common age-related small vessel pathology associated with intracerebral haemorrhage …

Vasomotion as a driving force for paravascular clearance in the awake mouse brain

SJ van Veluw, SS Hou, M Calvo-Rodriguez… - Neuron, 2020 - cell.com
Paravascular drainage of solutes, including β-amyloid (Aβ), appears to be an important
process in brain health and diseases such as Alzheimer's disease (AD) and cerebral …

Diagnosis of cerebral amyloid angiopathy: evolution of the Boston criteria

SM Greenberg, A Charidimou - Stroke, 2018 - Am Heart Assoc
492 Stroke February 2018 lobar hemorrhages required for probable CAA, or alternatively
preclude probable CAA if in deep territories. The rationale for counting all types of …

Emerging concepts in sporadic cerebral amyloid angiopathy

A Charidimou, G Boulouis, ME Gurol, C Ayata… - Brain, 2017 - academic.oup.com
Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and
a largely untreatable cause of intracerebral haemorrhage and contributor to age-related …

Prevalence of cerebral amyloid angiopathy: a systematic review and meta‐analysis

L Jäkel, AM De Kort, CJM Klijn… - Alzheimer's & …, 2022 - Wiley Online Library
Reported prevalence estimates of sporadic cerebral amyloid angiopathy (CAA) vary widely.
CAA is associated with cognitive dysfunction and intracerebral hemorrhage, and linked to …

Dysfunction of the blood–brain barrier in Alzheimer's disease: evidence from human studies

C Kurz, L Walker, BS Rauchmann… - Neuropathology and …, 2022 - Wiley Online Library
The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

Z Jaunmuktane, S Mead, M Ellis, JDF Wadsworth… - Nature, 2015 - nature.com
More than two hundred individuals developed Creutzfeldt–Jakob disease (CJD) worldwide
as a result of treatment, typically in childhood, with human cadaveric pituitary-derived growth …