L Muzio, A Viotti, G Martino - Frontiers in neuroscience, 2021 - frontiersin.org
Microglia are the resident macrophages of the central nervous system (CNS) acting as the first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …
M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigra pars compacta …
A García-Sánchez, AG Miranda-Díaz… - Oxidative Medicine …, 2020 - Wiley Online Library
Oxidative stress (OS) has the ability to damage different molecules and cellular structures, altering the correct function of organs and systems. OS accumulates in the body by …
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …
PR Angelova, N Esteras… - Medicinal Research …, 2021 - Wiley Online Library
The world's population aging progression renders age‐related neurodegenerative diseases to be one of the biggest unsolved problems of modern society. Despite the progress in …
D Ha, N Yang, V Nadithe - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Exosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes …
A Tarafdar, G Pula - International journal of molecular sciences, 2018 - mdpi.com
For a number of years, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) was synonymous with NOX2/gp91phox and was considered to be a peculiarity of …
Exosomes are naturally occurring nanosized vesicles that have attracted considerable attention as drug delivery vehicles in the past few years. Exosomes are comprised of natural …
Y Tang, W Le - Molecular neurobiology, 2016 - Springer
One of the most striking hallmarks shared by various neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease (AD), and amyotrophic lateral sclerosis, is …