Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites,
including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and …

Trypanosomiasis has been recognized as a scourge in sub-Saharan Africa for centuries.
The disease, caused by protozoan parasites of the Trypanosoma genus, is a major cause of …

Although many studies have demonstrated that components of the hemostatic system may
be involved in signaling leading to cancer progression, the potential mechanisms by which …

Situated between the circulation and the brain, the blood–brain barrier (BBB) protects the
brain from circulating toxins while securing a specialized environment for neuro-glial …

Trypanosoma brucei is a protozoan parasite that causes human and animal African
trypanosomiases (HAT and AAT). In the mammalian host, the parasite lives entirely …

The circumventricular organs (CVOs) are located around the brain ventricles, lack a blood-
brain barrier (BBB) and sense blood-derived molecules. This review discusses recent …

Glycolysis and glyconeogenesis play crucial roles in the ATP supply and synthesis of
glycoconjugates, important for the viability and virulence, respectively, of the human …

The extracellular parasite Trypanosoma brucei causes human African trypanosomiasis
(HAT), also known as sleeping sickness. Trypanosomes are transmitted by tsetse flies and …

Given that over 2% of the human genome codes for proteolytic enzymes and their inhibitors,
it is not surprising that proteinases serve many physiologic-pathophysiological roles. In this …

Different types of shed vesicles as, for example, exosomes, plasma-membrane-derived
vesicles or microparticles, are the focus of intense research in view of their potential role in …