Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

The Homeodomain-interacting protein kinase (Hipk) family of proteins plays diverse, and at
times conflicting, biological roles in normal development and disease. In this review we will …

Homeodomain interacting protein kinase-2 (HIPK2) is a member of the HIPK family of stress-
responsive kinases that modulates cell growth, apoptosis, proliferation and development …

Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and
are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) …

Speckle-type Poz protein (SPOP), an E3 ubiquitin ligase adaptor, is the most frequently
mutated gene in prostate cancer. The SPOP-mutated subtype of prostate cancer shows high …

Despite the search for new therapeutic strategies for gastric cancer (GC), there is much
evidence of progression due to resistance to chemotherapy. Multidrug resistance (MDR) is …

The function of many protein kinases is controlled by the phosphorylation of a critical
tyrosine residue in the activation loop. Dual specificity tyrosine‐phosphorylation‐regulated …

Homeodomain-interacting protein kinase 1 (HIPK1) is majorly found in the nucleoplasm.
HIPK1 is associated with cell proliferation, tumor necrosis factor-mediated cellular apoptosis …

Protein kinase C (PKC) isozymes are maintained in a'ready-to-go'but'safe'autoinhibited
conformation until second messenger binding unleashes an autoinhibitory pseudosubstrate …

Biochemical reactions often occur at low copy numbers but at once in crowded and diverse
environments. Space and stochasticity therefore play an essential role in biochemical …