Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Heterogeneous Catalysis and Parahydrogen‐Induced Polarization

EV Pokochueva, DB Burueva, OG Salnikov… - …, 2021 - Wiley Online Library
Parahydrogen‐induced polarization with heterogeneous catalysts (HET‐PHIP) has been a
subject of extensive research in the last decade since its first observation in 2007. While …

Instrumentation for hydrogenative parahydrogen-based hyperpolarization techniques

AB Schmidt, CR Bowers, K Buckenmaier… - Analytical …, 2022 - ACS Publications
The unique properties of the entangled, antisymmetric nuclear spin state of dihydrogen,
parahydrogen (pH2), has intrigued physicists, chemists, and other scientists for almost a …

Metabolic Tumor Imaging with Rapidly Signal‐Enhanced 1‐13C‐Pyruvate‐d3

T Hune, S Mamone, H Schroeder, AP Jagtap… - …, 2023 - Wiley Online Library
The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is
possible to perform metabolic imaging to reveal not only the exact location of a tumor, but …

Real-Time Nuclear Magnetic Resonance Detection of Fumarase Activity Using Parahydrogen-Hyperpolarized [1-13C]Fumarate

J Eills, E Cavallari, C Carrera, D Budker… - Journal of the …, 2019 - ACS Publications
Hyperpolarized fumarate can be used as a probe of real-time metabolism in vivo, using
carbon-13 magnetic resonance imaging. Dissolution dynamic nuclear polarization is …

[HTML][HTML] Hydrogenative-PHIP polarized metabolites for biological studies

F Reineri, E Cavallari, C Carrera, S Aime - Magnetic Resonance Materials …, 2021 - Springer
ParaHydrogen induced polarization (PHIP) is an efficient and cost-effective
hyperpolarization method, but its application to biological investigations has been …

Hyperpolarizing Concentrated Metronidazole 15NO2 Group over Six Chemical Bonds with More than 15 % Polarization and a 20 Minute Lifetime

RV Shchepin, JR Birchall, NV Chukanov… - … A European Journal, 2019 - Wiley Online Library
The NMR hyperpolarization of uniformly 15N‐labeled [15N3] metronidazole is demonstrated
by using SABRE‐SHEATH. In this antibiotic, the 15NO2 group is hyperpolarized through …

Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole

K MacCulloch, A Browning, P TomHon… - Analytical …, 2023 - ACS Publications
Hyperpolarization modalities overcome the sensitivity limitations of NMR and unlock new
applications. Signal amplification by reversible exchange (SABRE) is a particularly cheap …

15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields

OG Salnikov, NV Chukanov, A Svyatova… - Angewandte …, 2021 - Wiley Online Library
Nimorazole belongs to the imidazole‐based family of antibiotics to fight against anaerobic
bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as …

15N MRI of SLIC‐SABRE Hyperpolarized 15N‐Labelled Pyridine and Nicotinamide

A Svyatova, IV Skovpin, NV Chukanov… - … A European Journal, 2019 - Wiley Online Library
Abstract Magnetic Resonance Imaging (MRI) is a powerful non‐invasive diagnostic method
extensively used in biomedical studies. A significant limitation of MRI is its relatively low …