The impact of AlphaFold Protein Structure Database on the fields of life sciences

M Varadi, S Velankar - Proteomics, 2023 - Wiley Online Library
Arguably, 2020 was the year of high‐accuracy protein structure predictions, with AlphaFold
2.0 achieving previously unseen accuracy in the Critical Assessment of Protein Structure …

Aspects of phage-based vaccines for protein and epitope immunization

M Palma - Vaccines, 2023 - mdpi.com
Because vaccine development is a difficult process, this study reviews aspects of phages as
vaccine delivery vehicles through a literature search. The results demonstrated that because …

PDBe and PDBe‐KB: Providing high‐quality, up‐to‐date and integrated resources of macromolecular structures to support basic and applied research and education

M Varadi, S Anyango, SD Appasamy… - Protein …, 2022 - Wiley Online Library
The archiving and dissemination of protein and nucleic acid structures as well as their
structural, functional and biophysical annotations is an essential task that enables the …

Virus-like particles derived from bacteriophage MS2 as antigen scaffolds and RNA protective shells

A Naskalska, JG Heddle - Nanomedicine, 2024 - Taylor & Francis
The versatile potential of bacteriophage MS2-derived virus-like particles (VLPs) in medical
biotechnology has been extensively studied during the last 30 years. Since the first reports …

Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans

C Lu, J Wang, G Zhong - Infection and immunity, 2023 - Am Soc Microbiol
To search for subunit vaccine candidates, immunogenic chlamydial antigens identified in
humans were evaluated for protection against both infection and pathology in a mouse …

MS2 Virus-like Particles as a Versatile Peptide Presentation Platform: Insights into the Deterministic Abilities for Accommodating Heterologous Peptide Lengths

M Dang, LJ Wu, SR Zhang, JR Zhu, YZ Hu… - ACS Synthetic …, 2023 - ACS Publications
Virus-like particles (VLPs) are nanostructures with the potential to present heterologous
peptides at high density, thereby triggering heightened immunogenicity. RNA bacteriophage …

Bacteriophage virus-like particles: Platforms for vaccine design

E Tumban - Bacteriophages: Methods and Protocols, 2023 - Springer
Virus-like particles (VLPs) derived from bacteriophages have many applications in
biomedical sciences, especially in the development of candidate vaccines against viral and …

Advances in Chlamydia trachomatis Vaccination: Unveiling the Potential of Major Outer Membrane Protein Derivative Constructs

C Kiekens, SA Morré, D Vanrompay - Microorganisms, 2024 - mdpi.com
Chlamydia (C.) trachomatis, a leading cause of sexually transmitted infections (STIs)
worldwide, continues to be a significant public health concern. The majority of infections are …

A bacteriophage virus-like particle vaccine against oxycodone elicits high-titer and long-lasting antibodies that sequester drug in the blood

IG Romano, SB Core, NR Lee, C Mowry… - Vaccine, 2024 - Elsevier
Opioid use disorder (OUD) and opioid overdoses are public health emergencies. In 2021,
80,000 opioid overdose associated deaths were reported in the United States. Despite the …

Effects of prime-boost strategies on the protective efficacy and immunogenicity of a PLGA (85:15)-encapsulated Chlamydia recombinant MOMP nanovaccine

R Sahu, R Verma, TE Egbo… - Pathogens and …, 2024 - academic.oup.com
To begin to optimize the immunization routes for our reported PLGA-rMOMP nanovaccine
[PLGA-encapsulated Chlamydia muridarum (Cm) recombinant major outer membrane …