Publisher Summary This chapter focuses on the most well characterized inhibitors—cystatin
C—and provide some information on its structure, biochemical properties, its role in normal …

Low molecular-mass plasma proteins play a key role in health and disease. Cystatin C is an
endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily. The …

Chicken egg white cystatin was first described in the late 1960s. Since then, our knowledge
about a superfamily of similar proteins present in mammals, birds, fish, insects, plants and …

The crystal structure of human cystatin C, a protein with amyloidogenic properties and a
potent inhibitor of cysteine proteases, reveals how the protein refolds to produce very tight …

Clinical biochemists have long known the analytical and clinical limitations of creatinine and
creatinine clearance measurement in the assessment of glomerular filtration rate (GFR). This …

We have investigated the inhibition of the recently identified family C13 cysteine peptidase,
pig legumain, by human cystatin C. The cystatin was seen to inhibit enzyme activity by …

Cystatins, the classical inhibitors of C1 cysteine proteinases, have been extensively studied
and reviewed in the literature. Over the last 20 years, however, proteins containing cystatin …

Cysteine proteases (CPs) are responsible for many biochemical processes occurring in
living organisms and they have been implicated in the development and progression of …

Cystatins, an amyloid-forming structural superfamily, form highly stable, domain-swapped
dimers at physiological protein concentrations. In chicken cystatin, the active monomer is a …

A previously undescribed human member of the cystatin superfamily called cystatin F has
been identified by expressed sequence tag sequencing in human cDNA libraries. A full …