Genetics of substance use disorders in the era of big data
J Gelernter, R Polimanti - Nature Reviews Genetics, 2021 - nature.com
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
Genetics of substance use disorders: a review
JD Deak, EC Johnson - Psychological medicine, 2021 - cambridge.org
Substance use disorders (SUDs) are prevalent and result in an array of negative
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder
with a major genetic component. Here, we present a genome-wide association study meta …
with a major genetic component. Here, we present a genome-wide association study meta …
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
As recreational use of cannabis is being decriminalized in many places and medical use
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
Genetic liability to substance use disorders can be parsed into loci that confer general or
substance-specific addiction risk. We report a multivariate genome-wide association meta …
substance-specific addiction risk. We report a multivariate genome-wide association meta …
Cannabis use disorder and subsequent risk of psychotic and nonpsychotic unipolar depression and bipolar disorder
Importance Cannabis use is increasing worldwide and is suspected to be associated with
increased risk of psychiatric disorders; however, the association with affective disorders has …
increased risk of psychiatric disorders; however, the association with affective disorders has …
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction
Despite an estimated heritability of~ 50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide …
Despite the large toll of opioid use disorder (OUD), genome-wide association studies
(GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale …
(GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale …
Transcriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice
CJ Browne, R Futamura, A Minier-Toribio, EM Hicks… - Science …, 2023 - science.org
Opioid use disorder (OUD) looms as one of the most severe medical crises facing society.
More effective therapeutics will require a deeper understanding of molecular changes …
More effective therapeutics will require a deeper understanding of molecular changes …
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …