1. DENDRIMERS AND GENE DELIVERY Gene therapy represents a promising option for
the treatment of diseases such as inherited disorders, viral infections, and cancers. 1− 3 A …

Abstract The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …

The use of poly (propylenimine)(PPI) dendrimers as gene delivery vectors is limited by their
low transfection efficacy and serious cytotoxicity. In this study, we prepare a series of efficient …

Aberrant activation of the Wnt signaling pathway is a major trait of many human cancers.
Due to its vast implications in tumorigenesis and progression, the Wnt pathway has attracted …

Iodide (I−) metabolism is crucial for the synthesis of thyroid hormones (THs) in the thyroid
and the subsequent action of these hormones in the organism. I− is principally transported …

Gene therapy has great potential to bring tremendous changes in treatment of various
diseases and disorders. However, one of the impediments to successful gene therapy is the …

Dendritic polymers are highly branched polymers with controllable structures, which
possess a large population of terminal functional groups, low solution or melt viscosity, and …

We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of
radioiodine in neuroblastoma tumors after systemic nonviral polyplex-mediated sodium …

This paper reviews different techniques for analyzing the transfection efficiencies and
cytotoxicities of dendriplexes–complexes of nucleic acids with dendrimers. Analysis shows …

Earlier detection of cancers can dramatically improve the efficacy of available treatment
strategies. However, despite decades of effort on blood-based biomarker cancer detection …