Background Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of
the immune system and leads to the photoaging state which is reminiscent of chronological …

Ultraviolet (UV) radiation is a ubiquitous component of the environment that has important
effects on a wide range of cell functions. Short-wavelength UVB radiation induces sunburn …

Obesity increases the risk of cancers, including hepatocellular carcinomas (HCC). However,
the precise molecular mechanisms through which obesity promotes HCC development are …

Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …

PGE 2, an essential homeostatic factor, is also a key mediator of immunopathology in
chronic infections and cancer. The impact of PGE 2 reflects the balance between its …

Abstract Prostaglandin E 2 (PGE 2) is a bioactive lipid that elicits a wide range of biological
effects associated with inflammation and cancer. PGE 2 exerts diverse effects on cell …

The ability of MSCs to modulate the inflammatory environment is well recognized, but
understanding the molecular mechanisms responsible for these properties is still far from …

Debate on appropriate triggers for transfusion of allogeneic blood products and their effects
on short-and long-term survival in surgical and critically ill patients continue with no …

Chronic inflammation is the basis of various chronic illnesses including cancer and vascular
diseases. However, much has yet to be learned how inflammation becomes chronic …

Chronic inflammation contributes to cancer development via multiple mechanisms. One
potential mechanism is that chronic inflammation can generate an immunosuppressive …