In vitro studies in primary or immortalized cells continue to be used to elucidate the essential
principles that govern the interactions between HIV-1 and isolated target cells. However …

Quantification of retroviruses in cell culture supernatants and other biological preparations is
required in a diverse spectrum of laboratories and applications. Methods based on antigen …

The potential to harness the effectiveness and specificity of the immune system underlies the
growing interest in cancer immunotherapy. One such approach uses bone marrow-derived …

Human immunodeficiency virus (HIV) Nef is a membrane-associated protein decreasing
surface expression of CD4, CD28, and major histocompatibility complex class I on infected …

The accessory HIV‐1 Nef protein plays a key role in AIDS pathogenesis. We recently
demonstrated that exogenous Nef triggers phenotypic and functional differentiation of …

The ability of HIV-1 to evade the host immune response leads to the establishment of
chronic infection. HIV-1 has been reported to up-regulate MHC I molecules on the surface of …

Homeobox genes are well known for their crucial role during embryogenesis but have also
been found to be critically involved in normal and leukemic hematopoiesis. Because most …

Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity,
influences the trafficking of a large number of surface receptors and interferes with TCR …

Human immunodeficiency virus (HIV)-1 Nef protein is an essential modulator of AIDS
pathogenesis and we have previously demonstrated that rNef enters uninfected human …

The efficacy and safety of recombinant human interferon gamma (rIFN-γ) in the reduction of
opportunistic disease in patients with advanced HIV-1 infection are assessed. A 12-month …