Effects and mechanisms of resveratrol on aging and age‐related diseases

DD Zhou, M Luo, SY Huang, A Saimaiti… - Oxidative medicine …, 2021 - Wiley Online Library
The aging of population has become an issue of great concern because of its rapid
increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be …

Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

DJM Fernández-Ayala, P Navas… - Experimental gerontology, 2020 - Elsevier
SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly
people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense …

Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins

CM Palmeira, JS Teodoro, JA Amorim… - Free radical biology and …, 2019 - Elsevier
The key role of mitochondria in oxidative metabolism and redox homeostasis explains the
link between mitochondrial dysfunction and the development of metabolic disorders …

The roles of coenzyme Q in disease: direct and indirect involvement in cellular functions

F Pallotti, C Bergamini, C Lamperti, R Fato - International journal of …, 2021 - mdpi.com
Coenzyme Q (CoQ) is a key component of the respiratory chain of all eukaryotic cells. Its
function is closely related to mitochondrial respiration, where it acts as an electron …

Six functions of respiration: Isn't it time to take control over ROS production in mitochondria, and aging along with it?

VP Skulachev, MY Vyssokikh, BV Chernyak… - International Journal of …, 2023 - mdpi.com
Cellular respiration is associated with at least six distinct but intertwined biological
functions.(1) biosynthesis of ATP from ADP and inorganic phosphate,(2) consumption of …

Intercellular mitochondrial transfer in the brain, a new perspective for targeted treatment of central nervous system diseases

Z Geng, S Guan, S Wang, Z Yu, T Liu… - CNS neuroscience & …, 2023 - Wiley Online Library
Aim Mitochondria is one of the important organelles involved in cell energy metabolism and
regulation and also play a key regulatory role in abnormal cell processes such as cell stress …

Carnitine acetyltransferase deficiency mediates mitochondrial dysfunction‐induced cellular senescence in dermal fibroblasts

MJ Song, CH Park, H Kim, S Han, SH Lee, DH Lee… - Aging …, 2023 - Wiley Online Library
Aging is accompanied by impaired mitochondrial function and accumulation of senescent
cells. Mitochondrial dysfunction contributes to senescence by increasing the levels of …

The emerging role of skeletal muscle mitochondrial dynamics in exercise and ageing

RA Casuso, JR Huertas - Ageing research reviews, 2020 - Elsevier
Mitochondria are the hub for energy production within living cells. They can undergo
morphological changes in response to nutrient availability and cellular stress. Here, we …

Anti-aging activity and modes of action of compounds from natural food sources

L Song, S Zhang - Biomolecules, 2023 - mdpi.com
Aging is a natural and inescapable phenomenon characterized by a progressive
deterioration of physiological functions, leading to increased vulnerability to chronic …

Secondary CoQ10 deficiency, bioenergetics unbalance in disease and aging

P Navas, MV Cascajo, M Alcázar‐Fabra… - Biofactors, 2021 - Wiley Online Library
Abstract Coenzyme Q10 (CoQ10) deficiency is a rare disease characterized by a decreased
accumulation of CoQ10 in cell membranes. Considering that CoQ10 synthesis and most of …