Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons
and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the …

Spinal cord injury (SCI) is a neurological disorder associated with the loss of sensory and
motor function. Understanding the precise dysregulated signaling pathways, especially …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy is a catabolic process that degrades cytoplasmic constituents and organelles in
the lysosome, thus serving an important role in cellular homeostasis and protection against …

Abstract Background and Aim: Increasing evidence suggests that spinal cord injury (SCI)-
induced defects in autophagic flux may contribute to an impaired ability for neurological …

Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake
results in protease leakage. Whether limited leakage of lysosomal contents into the cytosol …

Extracellular vesicles (EVs) have been implicated mechanistically in the pathobiology of
neurodegenerative disorders, including central nervous system injury. However, the role of …

Necrosis that appears at the ischemic distal end of random-pattern skin flaps increases the
pain and economic burden of patients. Necroptosis is thought to contribute to flap necrosis …

Autophagy is a physiological process that helps maintain a balance between the
manufacture of cellular components and breakdown of damaged organelles and other toxic …

Central nervous system (CNS) trauma, including traumatic brain injury (TBI) and spinal cord
injury (SCI), remains a leading cause for morbidity and mortality worldwide. Past research …