Musculoskeletal trauma leading to broken and damaged bones and soft tissues can be a life-
threating event. Modern orthopaedic trauma surgery, combined with innovation in medical …

Background Indications for the use of negative pressure wound therapy (NPWT) are broad
and include prophylaxis for surgical site infections (SSIs). Existing evidence for the …

Importance Following surgery to treat major trauma–related fractures, deep wound infection
rates are high. It is not known if negative pressure wound therapy can reduce infection rates …

Background Traumatic wounds (wounds caused by injury) range from abrasions and minor
skin incisions or tears, to wounds with extensive tissue damage or loss as well as damage to …

Integrins have been the research focus of cell-extracellular matrix adhesion (ECM) and
cytokine receptor signal transduction. They are involved in the regulation of bone …

Soft tissue management and fracture fixation including initial external fixation in Gustilo-
Anderson type II and type III open fractures are cornerstones in the treatment but details on …

At present, effective fixation and anti-infection implant materials represent the mainstay for
the treatment of open fractures. However, external fixation can cause nail tract infections and …

Fracture-related infections (FRIs) are among the most common complications following
fracture fixation, and they have a huge economic and functional impact on patients. Because …

Background Open tibia fractures are a common injury following road traffic collisions and
place a large economic burden on patients and healthcare systems. Summarising their …

Background Injuries are a major cause of disability globally and injury incidence is rapidly
increasing, largely due to road traffic injuries in low-income and middle-income countries …