Understanding the continuum between high-risk myelodysplastic syndrome and acute myeloid leukemia

PD Zavras, I Sinanidis, P Tsakiroglou… - International journal of …, 2023 - mdpi.com
Myelodysplastic syndrome (MDS) is a clonal hematopoietic neoplasm characterized by
bone marrow dysplasia, failure of hematopoiesis and variable risk of progression to acute …

Maintenance with hypomethylating agents after allogeneic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome: a systematic review …

S Kungwankiattichai, B Ponvilawan, C Roy… - Frontiers in …, 2022 - frontiersin.org
Introduction Hypomethylating agents (HMAs) seem to have a range of properties favorable
to post-allogeneic hematopoietic stem cell transplantation (allo-SCT) maintenance in acute …

Gilteritinib: The Story of a Proceeding Success into Hard-to-Treat FLT3-Mutated AML Patients

M Molica, S Perrone, M Rossi - Journal of Clinical Medicine, 2023 - mdpi.com
The traditionally dismal outcome of acute myeloid leukemia (AML) patients carrying the FMS-
related tyrosine kinase 3 (FLT3) mutations has been mitigated by the recent introduction of …

[HTML][HTML] GITMO Registry study on allogeneic transplantation in patients aged≥ 60 years from 2000 to 2017: improvements and criticisms

M Malagola, N Polverelli, V Rubini, M Martino… - … and Cellular Therapy, 2022 - Elsevier
Today, allogeneic stem cell transplantation (allo-SCT) can be offered to patients up to age
70 to 72 years and represents one of the most effective curative treatments for many …

Current status and perspectives of allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia

S Servais, Y Beguin, F Baron - Stem Cells Translational …, 2022 - academic.oup.com
As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best
chance for durable remission in older patients (≥ 60 years) with acute myeloid leukemia …

[HTML][HTML] Therapeutic targeting in pediatric acute myeloid leukemia with aberrant HOX/MEIS1 expression

KL Juul-Dam, NN Shukla, TM Cooper… - European Journal of …, 2023 - Elsevier
Despite advances in the clinical management of childhood acute myeloid leukemia (AML)
during the last decades, outcome remains fatal in approximately one third of patients …

Patient and Physician Preferences for Acute Myeloid Leukemia Maintenance Treatments Following Hematopoietic Stem Cell Transplantation

L Saini, JD Griffin, BJ Pandya, MV Shah… - Patient preference …, 2023 - Taylor & Francis
Purpose This study assessed and compared preferences for treatment attributes of
maintenance therapies post-hematopoietic stem cell transplantation (HSCT) in patients with …

Maintenance therapy for AML after allogeneic HCT

RK Nayak, YB Chen - Frontiers in Oncology, 2022 - frontiersin.org
Allogeneic hematopoietic cell transplant (allo-HCT) for eligible patients with acute myeloid
leukemia (AML) in first complete remission is a central treatment paradigm to achieve …

Dose-finding trial of azacitidine as post-transplant maintenance for high-risk MDS: a KSGCT prospective study

Y Najima, T Tachibana, Y Takeda, Y Koda… - Annals of …, 2022 - Springer
Abstract This 3+ 3 dose-escalation phase I multicenter study investigated the optimal dose of
azacitidine (AZA) for post-hematopoietic stem cell transplantation (HSCT) maintenance …

Overcoming relapse: prophylactic or pre-emptive use of azacitidine or FLT3 inhibitors after allogeneic transplantation for AML or MDS

Y Najima - International Journal of Hematology, 2023 - Springer
Relapse remains the most critical obstacle in treatment by allogeneic hematopoietic stem
cell transplantation (HSCT). Non-relapse mortality has improved annually, but relapse …