Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …

B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An
extremely complicated and multifactorial interaction among various genetic and …

Calcium signals in cells of the immune system participate in the regulation of cell
differentiation, gene transcription and effector functions. An increase in intracellular levels of …

To advance our understanding and treatment of disease, research immunologists have
been called-upon to place more centralized emphasis on impactful human studies. Such …

Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations derived
from the involvement of multiple organs including the kidneys, joints, nervous system and …

INTRODUCTION Programmed cell death occurs throughout life in all tissues of the body,
and more than a billion cells die every day as part of normal processes. Thus, rapid and …

Systemic lupus erythematosus, a prototypical systemic autoimmune disease, is the result of
a series of interactions within the immune system that ultimately lead to the loss of self …

Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by
production of autoantibodies and complex genetic inheritance,,. In a genome-wide scan …

Spleen tyrosine kinase (Syk) is a cytoplasmic protein tyrosine kinase well known for its
ability to couple immune cell receptors to intracellular signaling pathways that regulate …