Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

Microglia, the macrophages of the brain, are vital for brain homeostasis and have been
implicated in a broad range of brain disorders. Neuroinflammation has gained traction as a …

Recent evidence demonstrates that Crocus sativus L.(saffron) counteracts oxidative stress,
mitochondrial dysfunction and neuroinflammation, closely linked to initiation and …

Significance: The stria vascularis, located in the inner ear, consists of three layers, one of
which is the blood–labyrinth barrier (BLB). It is formed by endothelial cells, sealed together …

Skin aging is influenced by intrinsic and extrinsic factors that progressively impair skin
functionality over time. Investigating the skin aging process requires thorough research …

Neurodegenerative diseases have multifactorial pathogenesis, mainly involving
neuroinflammatory processes. Finding drugs able to treat these diseases, expecially …

There is substantial experimental and clinical interest in providing effective ways to both
prevent and slow the onset of hearing loss. Auditory hair cells, which occur along the basilar …

Pancreatic cancer adenocarcinoma (PDAC) is a lethal disease, with the lowest 5-years
survival rate of all cancers due to late diagnosis. Despite the advance and success of …

Much of nutrition research has been conventionally based on the use of simplistic in vitro
systems or animal models, which have been extensively employed in an effort to better …

Globally, age-related diseases represent a significant public health concern among the
elderly population. In aging, healthy organs and tissues undergo structural and functional …