Role of MIF cytokine/CD74 receptor pathway in protecting against injury and promoting repair

L Farr, S Ghosh, S Moonah - Frontiers in immunology, 2020 - frontiersin.org
Wound healing after an injury is essential for life. An in-depth understanding of the healing
process is necessary to ultimately improve the currently limited treatment options for patients …

Tissue Destruction Caused by Entamoeba histolytica Parasite: Cell Death, Inflammation, Invasion, and the Gut Microbiome

S Ghosh, J Padalia, S Moonah - Current clinical microbiology reports, 2019 - Springer
Abstract Purpose of Review Entamoeba histolytica is a protozoan parasite that causes
amebiasis, which remains a significant cause of morbidity and mortality worldwide. E …

[HTML][HTML] CD74 signaling links inflammation to intestinal epithelial cell regeneration and promotes mucosal healing

L Farr, S Ghosh, N Jiang, K Watanabe, M Parlak… - Cellular and molecular …, 2020 - Elsevier
Background & Aims The inflammatory response to intestinal damage promotes healing
through mechanisms that are incompletely understood. Gene expression of cluster of …

Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-κB/STAT3 and NF-κB/CSN5 signaling pathways

Z Ruan, M Liang, L Shang, M Lai, X Deng, X Su - Pancreatology, 2021 - Elsevier
Background Pancreatic cancer (PC) is a highly fatal malignancy with few effective therapies
currently available. Recent studies have shown that PD-L1 inhibitors could be potential …

Drug repurposing of the alcohol abuse medication disulfiram as an anti-parasitic agent

DA Shirley, I Sharma, CA Warren… - Frontiers in cellular and …, 2021 - frontiersin.org
Parasitic infections contribute significantly to worldwide morbidity and mortality. Antibiotic
treatment is essential for managing patients infected with these parasites since control is …

Parasite-produced MIF cytokine: role in immune evasion, invasion, and pathogenesis

S Ghosh, N Jiang, L Farr, R Ngobeni… - Frontiers in …, 2019 - frontiersin.org
Protozoan parasites represent a major threat to health and contribute significantly to
morbidity and mortality worldwide, especially in developing countries. This is further …

Distinct roles of MIF in the pathogenesis of ischemic heart disease

L Zhao, BH Zhao, A Ruze, QL Li, AX Deng… - Cytokine & Growth Factor …, 2024 - Elsevier
The role of macrophage migration inhibitory factor (MIF) as a multifunctional cytokine in
immunomodulation and inflammatory response is increasingly appreciated. Ischemic heart …

COP9 signalosome is an essential and druggable parasite target that regulates protein degradation

S Ghosh, L Farr, A Singh, LA Leaton, J Padalia… - PLoS …, 2020 - journals.plos.org
Understanding how the protozoan protein degradation pathway is regulated could uncover
new parasite biology for drug discovery. We found the COP9 signalosome (CSN) conserved …

Ubiquitin-like modifiers: emerging regulators of protozoan parasites

M Karpiyevich, K Artavanis-Tsakonas - Biomolecules, 2020 - mdpi.com
Post-translational protein regulation allows for fine-tuning of cellular functions and involves a
wide range of modifications, including ubiquitin and ubiquitin-like modifiers (Ubls). The …

Entamoeba histolytica: Membrane and Non-Membrane Protein Structure, Function, Immune Response Interaction, and Vaccine Development

N Jasni, S Saidin, WW Kin, N Arifin, N Othman - Membranes, 2022 - mdpi.com
Entamoeba histolytica is a protozoan parasite that is the causative agent of amoebiasis. This
parasite has caused widespread infection in India, Africa, Mexico, and Central and South …