Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

The human cortex comprises diverse cell types that emerge from an initially uniform
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …

The size and surface area of the mammalian brain are thought to be critical determinants of
intellectual ability. Recent studies show that development of the gyrated human neocortex …

The size and extent of folding of the mammalian cerebral cortex are important factors that
influence a species' cognitive abilities and sensorimotor skills. Studies in various animal …

Neurons in the developing rodent cortex are generated from radial glial cells that function as
neural stem cells. These epithelial cells line the cerebral ventricles and generate …

Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …

Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous
system. These cells have diverse roles in the maintenance of neurological function. In the …

The neocortex of the adult brain consists of neurons and glia that are generated by
precursor cells of the embryonic ventricular zone. In general, glia are generated after …

One of the most prominent features of the human brain is the fabulous size of the cerebral
cortex and its intricate folding. Cortical folding takes place during embryonic development …