From target discovery to clinical drug development with human genetics
The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …
decades were anticipated to result in many innovative therapies. Here we investigate the …
Vascular smooth muscle cells in atherosclerosis
GL Basatemur, HF Jørgensen, MCH Clarke… - Nature reviews …, 2019 - nature.com
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …
Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …
new informatics approaches alongside conventional statistical methods. Systems theories …
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk
Coronary artery disease (CAD) is a complex inflammatory disease involving genetic
influences across cell types. Genome-wide association studies have identified over 200 loci …
influences across cell types. Genome-wide association studies have identified over 200 loci …
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
The challenge of linking intergenic mutations to target genes has limited molecular
understanding of human diseases. Here we show that H3K27ac HiChIP generates high …
understanding of human diseases. Here we show that H3K27ac HiChIP generates high …
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated …
Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial
infarction primarily affecting women. It is not known to what extent SCAD is genetically …
infarction primarily affecting women. It is not known to what extent SCAD is genetically …
The microbiome in allergic disease: current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & …
YJ Huang, BJ Marsland, S Bunyavanich… - Journal of Allergy and …, 2017 - Elsevier
PRACTALL is a joint initiative of the American Academy of Allergy, Asthma & Immunology
and the European Academy of Allergy and Clinical Immunology to provide shared evidence …
and the European Academy of Allergy and Clinical Immunology to provide shared evidence …
CARMN Is an Evolutionarily Conserved Smooth Muscle Cell–Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin
Background: Vascular homeostasis is maintained by the differentiated phenotype of
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …
Decoding the genetic and epigenetic basis of asthma
Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …
Single-cell epigenomics and functional fine-mapping of atherosclerosis GWAS loci
T Örd, K Õunap, LK Stolze, R Aherrahrou… - Circulation …, 2021 - Am Heart Assoc
Rationale: Genome-wide association studies have identified hundreds of loci associated
with coronary artery disease (CAD). Many of these loci are enriched in cisregulatory …
with coronary artery disease (CAD). Many of these loci are enriched in cisregulatory …