The psychoactive constituent in cannabis, Δ9-tetrahydrocannabinol (THC), was isolated in
the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous …

In the young of many mammalian species, including humans, a vigorous and highly
rewarding social activity is abundantly expressed, known as social play behaviour. Social …

Despite extensive study over the past decades, available treatments for schizophrenia are
only modestly effective and cause serious metabolic and neurological side effects …

Cognitive function in humans depends on the complex and interplay between multiple body
systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which …

Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …

The cannabinoid type two receptors (CB2), an important component of the endocannabinoid
system, have recently emerged as neuromodulators and therapeutic targets for …

Exploring the role of cannabinoid CB 2 receptors in the brain, we present evidence of CB 2
receptor molecular and functional interaction with cannabinoid CB 1 receptors. Using …

The endocannabinoid system (ECS), comprising two G protein-coupled receptors (the
cannabinoid receptors 1 and 2 [CB1 and CB2] for marijuana's psychoactive principle∆ 9 …

The possibility that mechanisms of synaptic modulation differ between males and females
has far-reaching implications for understanding brain disorders that vary between the sexes …

Major depressive disorder is a high-impact, debilitating disease and it is currently
considered the most prevalent mental illness. It is associated with disability, as well as …