Abstract T helper type 1 (Th1) lymphocytes secrete secrete interleukin (IL)-2, interferon-γ,
and lymphotoxin-α and stimulate type 1 immunity, which is characterized by intense …

Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial
infection that elicits an extraordinary range of cellular immune responses in humans. The …

Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci
have been the prototypical candidates for genetic susceptibility to infectious disease …

Review this adequately. What is certain is that BCG is not effective for muscle-invasive
disease, or for tumours that lie out of direct contact with BCG such as those deep within the …

OBJECTIVES: To describe the clinical and immunological features of crusted scabies in a
prospectively ascertained cohort of 78 patients. METHODS: All patients requiring inpatient …

Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Host genetic factors including major histocompatibility complex (MHC) polymorphisms
influence both susceptibility to leprosy per se and also to leprosy type. Non-MHC genes may …

Background Patients with localized tuberculoid and generalized lepromatous leprosy show
respectively Th1 and Th2 cytokine profile. Additionally, other patients in both types of leprosy …

Leprosy, caused by noncultivable Mycobacterium leprae (ML), has varied manifestations,
which are associated with the host immune responses. The dermal involvement is …

Background 50% of leprosy patients suffer from episodes of Type 1/reversal reactions (RR)
and Type 2/Erythema Nodosum Leprosum (ENL) reactions which lead to morbidity and …