With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Cardiovascular diseases are among the leading causes of death worldwide. Reactive
oxygen species (ROS) can act as damaging molecules but also represent central hubs in …

Oxidative stress has a significant impact on the development and progression of common
human pathologies, including cancer, diabetes, hypertension and neurodegenerative …

Background: The epigenetic effects of individual environmental toxicants in tobacco remain
largely unexplored. Cadmium (Cd) has been associated with smoking-related health effects …

Abstract Tet-enzyme-mediated 5-hydroxymethylation of cytosines in DNA plays a crucial role
in mouse embryonic stem cells (ESCs). In RNA also, 5-hydroxymethylcytosine (5hmC) has …

Abstract Significance: Highly prevalent in Western cultures, obesity, metabolic syndrome,
and diabetes increase the risk of cardiovascular morbidity and mortality and cost health care …

Background Per-and polyfluoroalkyl substances (PFAS) are chemicals that are resistant to
degradation and ubiquitous in our environments. PFAS may impact the developing …

In this study we evaluated and correlated the cytotoxic effects of zinc oxide nanoparticles
(ZnO-NPs) to the epigenetic modifications, using human embryonic kidney (HEK-293) cells …

Simple Summary Early embryo development is a dynamic and orchestrated event. Oxygen
plays a fundamental role in several key biological processes necessary to sustain and …