Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

Translation generally initiates with the AUG codon. While initiation at GUG and UUG is
permitted in prokaryotes (Archaea and Bacteria), cases of CUG initiation were recently …

Ternary complex (TC) and eIF4F complex assembly are the two major rate-limiting steps in
translation initiation regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway …

Protein phosphorylation is a crucial regulatory mechanism that controls many aspects of
cellular signaling. Casein kinase 2 (CK2), a constitutively expressed and active kinase …

BCL-2 family proteins are frequently aberrantly expressed in mantle cell lymphoma (MCL).
Recently, the BCL-2-specific inhibitor venetoclax has been approved by the US Food and …

Gain of function LRRK2‐G2019S is the most frequent mutation found in familial and
sporadic Parkinson's disease. It is expected therefore that understanding the cellular …

CK2 phosphorylates a wide variety of substrates, including translation initiation factors. A
mass spectrometric approach was used to identify residues phosphorylated by CK2, which …

Spalt-like proteins are Zinc finger transcription factors from Caenorhabditis elegans to
vertebrates, with critical roles in development. In vertebrates, four paralogues have been …

A previously described wheat germ protein kinase (Yan, TF, and Tao, M.(1982) J. Biol.
Chem. 257, 7037–7043) was identified unambiguously as CK2 using mass spectrometry …

ABSTRACT Death-associated protein 5 (DAP5) is an atypical isoform of the translation
initiation scaffolds eukaryotic initiation factor 4GI (eIF4GI) and eIF4GII (eIF4GI/II), which …