Background The time course of blood lactate levels could be helpful to assess a patient's
response to therapy. Although the focus of published studies has been largely on septic …

Background Aetiology and outcomes of sepsis in sub-Saharan Africa (sSA) are poorly
described; we performed a systematic review and meta-analysis to summarise the available …

Background Critical illness is a leading cause of morbidity and mortality in sub-Saharan
Africa (SSA). Identifying patients with the highest risk of death could help with resource …

Background Sepsis is a condition widely observed outside critical care areas. Aim To
examine the application of sepsis screening tools for early recognition of sepsis in general …

Background Knowledge of causes of sepsis in sub-Saharan Africa is limited. A better
understanding of the microbiology of bloodstream infections could improve outcomes …

Background Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality
in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been …

Background Despite the necessity of early recognition for an optimal outcome, sepsis often
remains unrecognized. Available tools for early recognition are rarely evaluated in low-and …

Background Reduced level of consciousness (LOC) is a common cause of presentation
among acutely ill adults in sub-Saharan Africa and is associated with high rates of mortality …

Objective The aim of the study was to describe the prevalence of hyperlactatemia and
emphasis on repeated lactate measurements in critically ill patients, and the associated …

Sepsis is common and represents a major public health burden with significant associated
morbidity and mortality. However, despite substantial advances in sepsis recognition and …