Gut-liver axis: Pathophysiological concepts and clinical implications

H Tilg, TE Adolph, M Trauner - Cell metabolism, 2022 - cell.com
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

[HTML][HTML] Gut microbiome and health: mechanistic insights

WM De Vos, H Tilg, M Van Hul, PD Cani - Gut, 2022 - gut.bmj.com
The gut microbiota is now considered as one of the key elements contributing to the
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …

The gut–liver axis and gut microbiota in health and liver disease

CL Hsu, B Schnabl - Nature Reviews Microbiology, 2023 - nature.com
The trillions of microorganisms in the human intestine are important regulators of health, and
disruptions in the gut microbial communities can cause disease. The gut, liver and immune …

Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Alcohol-associated liver disease

B Mackowiak, Y Fu, L Maccioni… - The Journal of Clinical …, 2024 - Am Soc Clin Investig
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …

Utilization of the microbiome in personalized medicine

K Ratiner, D Ciocan, SK Abdeen, E Elinav - Nature Reviews …, 2024 - nature.com
Inter-individual human variability, driven by various genetic and environmental factors,
complicates the ability to develop effective population-based early disease detection …

Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

M Modoux, N Rolhion, JH Lefevre, C Oeuvray… - Gut …, 2022 - Taylor & Francis
Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between the gut
microbiota and its host. However, factors regulating AhR within the gut, which is a complex …

[HTML][HTML] Commensal cow Roseburia reduces gut-dysbiosis-induced mastitis through inhibiting bacterial translocation by producing butyrate in mice

C Zhao, L Bao, M Qiu, K Wu, Y Zhao, L Feng, K Xiang… - Cell Reports, 2022 - cell.com
The precise mechanism by which gut dysbiosis contributes to the pathogenesis of
extraintestinal diseases and how commensal microbes mediate these processes remain …

Aryl hydrocarbon receptor activation by Lactobacillus reuteri tryptophan metabolism alleviates Escherichia coli-induced mastitis in mice

C Zhao, X Hu, L Bao, K Wu, L Feng, M Qiu… - PLoS …, 2021 - journals.plos.org
The intestinal microbiota has been associated with the occurrence and development of
mastitis, which is one of the most serious diseases of lactating women and female animals …

Arabinoxylan ameliorates type 2 diabetes by regulating the gut microbiota and metabolites

Q Nie, J Hu, H Chen, F Geng, S Nie - Food Chemistry, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) is a metabolic disease characterized by hyperglycemia.
Intake of dietary fiber is inversely associated with risks of T2D. Here, metabolomics and 16S …