Targeting and engineering long non-coding RNAs for cancer therapy
RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …
Domain generalization enables general cancer cell annotation in single-cell and spatial transcriptomics
Single-cell and spatial transcriptome sequencing, two recently optimized transcriptome
sequencing methods, are increasingly used to study cancer and related diseases. Cell …
sequencing methods, are increasingly used to study cancer and related diseases. Cell …
The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons
Synaptic function in neurons is modulated by local translation of mRNAs that are transported
to distal portions of axons and dendrites. The metastasis‐associated lung adenocarcinoma …
to distal portions of axons and dendrites. The metastasis‐associated lung adenocarcinoma …
Long Noncoding RNA MALAT1: Salt-Sensitive Hypertension
MM Khan, A Kirabo - International Journal of Molecular Sciences, 2024 - mdpi.com
Hypertension stands as the leading global cause of mortality, affecting one billion
individuals and serving as a crucial risk indicator for cardiovascular morbidity and mortality …
individuals and serving as a crucial risk indicator for cardiovascular morbidity and mortality …
M2 Tumor‐Associated Macrophages‐Derived Exosomal MALAT1 Promotes Glycolysis and Gastric Cancer Progression
Y Wang, J Zhang, H Shi, M Wang, D Yu, M Fu… - Advanced …, 2024 - Wiley Online Library
M2‐polarized tumor‐associated macrophages (M2 TAMs) promote cancer progression.
Exosomes mediate cellular communication in the tumor microenvironment (TME). However …
Exosomes mediate cellular communication in the tumor microenvironment (TME). However …
Three-dimensional computer vision for exploring heterogeneity in collective Cancer Invasion
Collective cancer invasion exhibits a hierarchical structure characterized by leader-follower
organization. Dynamic gene expression analysis of invading cells using nanobiosensors …
organization. Dynamic gene expression analysis of invading cells using nanobiosensors …
SNHG17 alters anaerobic glycolysis by resetting phosphorylation modification of PGK1 to foster pro-tumor macrophage formation in pancreatic ductal …
J Lin, Y Liu, P Liu, W Qi, J Liu, X He, Q Liu, Z Liu… - Journal of Experimental …, 2023 - Springer
Background Within the tumor immune microenvironment (TME), tumor-associated
macrophages (TAMs) are crucial in modulating polarization states to influence cancer …
macrophages (TAMs) are crucial in modulating polarization states to influence cancer …
Locked Nucleic Acid Oligonucleotides Facilitate RNA•LNA-RNA Triple-Helix Formation and Reduce MALAT1 Levels
KM Shivakumar, G Mahendran, JA Brown - International Journal of …, 2024 - mdpi.com
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and multiple endocrine
neoplasia-β (MENβ) are two long noncoding RNAs upregulated in multiple cancers, marking …
neoplasia-β (MENβ) are two long noncoding RNAs upregulated in multiple cancers, marking …
[HTML][HTML] LINC00839 in Human Disorders: Insights into its Regulatory Roles and Clinical Impact, with a Special Focus on Cancer
Y Hu, Y Hu, X Lu, H Luo, Z Chen - Journal of Cancer, 2024 - ncbi.nlm.nih.gov
LINC00839 has captured significant attention within a spectrum of human disorders,
including acute lung injury, osteoarthritis, and childhood obesity. Notably, aberrant …
including acute lung injury, osteoarthritis, and childhood obesity. Notably, aberrant …
The Non-coding Genome and Network Biology
RC Kelly, RA Morgan, M Brown, I Overton… - Systems Biology II, 2024 - Springer
A non-coding RNA (ncRNA) is a class of RNA that does not undergo translation. The DNA
sequence encoding a non-coding RNA referred to as an RNA gene. According to the RNA …
sequence encoding a non-coding RNA referred to as an RNA gene. According to the RNA …