The maintenance of muscle homeostasis is vital for life and health. Skeletal muscle atrophy
not only seriously reduces people's quality of life and increases morbidity and mortality, but …

Abstract Skeletal muscle makes up 30–40% of the total body mass. It is of great significance
in maintaining digestion, inhaling and exhaling, sustaining body posture, exercising …

Abstract Corticosteroids‐induced Dickkopf‐1 (DKK1) upregulation and Wnt signaling
inhibition result in bone metabolism disorder and steroid‐associated osteonecrosis (SAON) …

Diabetes and Alzheimer's disease (AD) place a significant burden on health care systems in
the world and its aging populations. These diseases have long been regarded as separate …

Lithium is most well-known for its mood-stabilizing effects in the treatment of bipolar
disorder. Due to its narrow therapeutic window (0.5-1.2 mM serum concentration), there is a …

Inhibiting glycogen synthase kinase 3 (GSK3) improves muscle function, metabolism, and
bone health in many diseases and conditions; however, whether GSK3 should be targeted …

Calcineurin is a Ca2+‐dependent serine/threonine phosphatase that dephosphorylates
nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus. In …

The monoamine hypothesis has dominated research on the pathophysiology of mood
disorders as well as the development of therapeutic drugs by over half a century. Nowadays …

Cardiac contractile function is largely mediated by the regulation of Ca2+ cycling throughout
the lifespan. The sarco (endo) plasmic reticulum Ca2+ ATPase (SERCA) pump is paramount …

Sarco (endo) plasmic reticulum Ca 2+-ATPase (SERCA) uncoupling in skeletal muscle and
mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige adipose tissue …