The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …

Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they
can die through programmed cell death upon the stimulation of specific signalling pathways …

Members of the nucleotide-binding domain and leucine-rich repeat (LRR)-containing (NLR)
family and the pyrin and HIN domain (PYHIN) family can form multiprotein complexes …

The nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing
3 (NLRP3) responds to a vast variety of stimuli, and activated NLRP3 forms an …

Abstract The NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is
an immunological sensor that detects a wide range of microbial-and host-derived signals …

Mitochondria are functionally versatile organelles. In addition to their conventional role of
meeting the cell's energy requirements, mitochondria also actively regulate innate immune …

Recent studies have offered a glimpse into the sophisticated mechanisms by which
inflammasomes respond to danger and promote secretion of interleukin (IL)-1β and IL-18 …

The NLRP 3 (NOD‐like receptor family, pyrin domain containing 3) inflammasome is a
multiprotein complex that orchestrates innate immune responses to infection and cell stress …

Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of
the cell that are responsible for the maturation of proinflammatory cytokines such as …

Assembly of the NLRP3 inflammasome activates caspase-1 and mediates the processing
and release of the leaderless cytokine IL-1β and thereby serves a central role in the …