ADMA: a key player in the relationship between vascular dysfunction and inflammation in atherosclerosis

L Dowsett, E Higgins, S Alanazi… - Journal of Clinical …, 2020 - mdpi.com
Atherosclerosis is a chronic cardiovascular disease which increases risk of major
cardiovascular events including myocardial infarction and stroke. Elevated plasma …

L-arginine-nitric oxide-asymmetric dimethylarginine pathway and the coronary circulation: translation of basic science results to clinical practice

A Cziráki, Z Lenkey, E Sulyok, I Szokodi… - Frontiers in …, 2020 - frontiersin.org
By 1980, it was thought that we already knew most of the major mechanisms regulating
vascular tone. However, after the somewhat serendipity discovery that endothelium is …

Relationship of asymmetric dimethylarginine (ADMA) with extent and functional severity of coronary atherosclerosis

F Mangiacapra, M Conte, C Demartini, O Muller… - International Journal of …, 2016 - Elsevier
Background Elevated serum levels of asymmetric dimethylarginine (ADMA) are associated
with endothelial dysfunction and atherogenesis. In patients with suspected coronary artery …

Nitric oxide-mediated coronary flow regulation in patients with coronary artery disease: recent advances

N Toda, S Tanabe, S Nakanishi - International Journal of …, 2011 - thieme-connect.com
Nitric oxide (NO) formed via endothelial NO synthase (eNOS) plays crucial roles in the
regulation of coronary blood flow through vasodilatation and decreased vascular resistance …

Elevated levels of Asymmetric Dimethylarginine (ADMA) in the pericardial fluid of cardiac patients correlate with cardiac hypertrophy

Z Nemeth, A Cziraki, S Szabados, B Biri, S Keki… - PloS one, 2015 - journals.plos.org
Background Pericardial fluid (PF) contains several biologically active substances, which
may provide information regarding the cardiac conditions. Nitric oxide (NO) has been …

ADMA predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus undergoing coronary angiography

F Heunisch, L Chaykovska, G von Einem, M Alter… - Medicine, 2017 - journals.lww.com
Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of the nitric oxide (NO)-
synthase and a biomarker of endothelial dysfunction (ED). ED plays an important role in the …

Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine

A Cziráki, Z Ajtay, Á Németh, Z Lenkey… - Coronary artery …, 2011 - journals.lww.com
Objectives We measured and compared serum asymmetric dimethylarginine (ADMA),
symmetric dimethylarginine (SDMA), and L-arginine levels in patients undergoing coronary …

Asymmetric Dimethylarginine Predicts One-year Recurrent Cardiovascular Events: Potential Biomarker of “Toxin Syndrome” in Coronary Heart Disease

H Xu, Z Chen, Q Shang, Z Gao, C Yu, D Shi… - Chinese journal of …, 2019 - Springer
Objective To examine the prognostic value of serum levels of asymmetric dimethylarginine
(ADMA) in patients with stable coronary heart disease (CHD) thus explore a potential …

Optimization of the separation of nda-derivatized methylarginines by capillary and microchip electrophoresis

TH Linz, CM Snyder, SM Lunte - Journal of laboratory …, 2012 - journals.sagepub.com
The methylated arginines (MAs) monomethylarginine (MMA), asymmetric dimethylarginine
(ADMA), and symmetric dimethylarginine (SDMA) have been shown to be independent …

Heat‐assisted extraction for the determination of methylarginines in serum by CE

TH Linz, SM Lunte - Electrophoresis, 2013 - Wiley Online Library
Methylarginines (MA s) are potent vasoconstrictors that have been reported to be present at
elevated concentrations in the blood of patients suffering from cardiovascular disease. To …