T-wave alternans (TWA) reflects every-other-beat alterations in the morphology of the
electrocardiogram ST segment or T wave in the setting of a constant heart rate, hence, in the …

A rapid growth in the incidence of diabetes and obesity has transpired to a major heath
issue and economic burden in the postindustrial world, with more than 29 million patients …

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …

Pre-existing Ca2+ handling abnormalities constitute the arrhythmogenic substrate in
patients developing postoperative atrial fibrillation (POAF), a common complication after …

Background Malignant ventricular arrhythmia (VA) is a major contributor to sudden cardiac
death (SCD) in patients with pulmonary arterial hypertension (PAH)-induced right heart …

Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca 2+ handling, promoting ectopic
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …

Rationale: Ca2+ alternans plays an essential role in cardiac alternans that can lead to
ventricular fibrillation, but the mechanism underlying Ca2+ alternans remains undefined …

Sarcoplasmic reticulum (SR) Ca2+ cycling is tightly regulated by ryanodine receptor (RyR)
Ca2+ release and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) Ca2+ uptake …

Pirarubicin (THP), an anthracycline anticancer drug, is a first‐line therapy for various solid
tumours and haematologic malignancies. However, THP can cause dose‐dependent …

Background Doxorubicin (Dox) is a potent chemotherapeutic agent, but its usage is limited
by dose-dependent cardiotoxicity. Intracellular calcium dysregulation has been reported to …