Correlation and association analyses in microbiome study integrating multiomics in health and disease

Y Xia - Progress in molecular biology and translational …, 2020 - Elsevier
Correlation and association analyses are one of the most widely used statistical methods in
research fields, including microbiome and integrative multiomics studies. Correlation and …

Pathophysiology of type 2 diabetes in sub-Saharan Africans

JH Goedecke, AE Mendham - Diabetologia, 2022 - Springer
Abstract Sub-Saharan Africa (SSA) is the region with the highest projected rates of increase
in type 2 diabetes (129% by 2045), which will exacerbate the already high prevalence of …

Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity

AE Mendham, JH Goedecke, Y Zeng, S Larsen… - Diabetologia, 2021 - Springer
Aims/hypothesis We sought to determine putative relationships among improved
mitochondrial respiration, insulin sensitivity and altered skeletal muscle lipids and …

Adiposity mediates the association between the dietary inflammatory index and markers of type 2 diabetes risk in middle-aged black South African women

A Mtintsilana, LK Micklesfield, E Chorell, T Olsson… - Nutrients, 2019 - mdpi.com
The dietary inflammatory index (DII®), a validated tool used to measure the inflammatory
potential of the diet, has been associated with metabolic disorders in various settings, but …

Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function

AE Mendham, S Larsen, C George, K Adams… - Scientific Reports, 2020 - nature.com
We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal
subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise …

Exercise intervention alters HDL subclass distribution and function in obese women

NJ Woudberg, AE Mendham, AA Katz… - Lipids in health and …, 2018 - Springer
Background Obesity is associated with a change in high-density lipoprotein (HDL) function
and subclass. Exercise training reduces cardiovascular risk in obese patients. We aimed to …

Changes in subcutaneous adipose tissue microRNA expression in response to exercise training in African women with obesity

C Pheiffer, S Dias, AE Mendham, B Jack, T Willmer… - Scientific Reports, 2022 - nature.com
The mechanisms that underlie exercise-induced adaptations in adipose tissue have not
been elucidated, yet, accumulating studies suggest an important role for microRNAs …

Pathogenesis of type 2 diabetes risk in black Africans: a South African perspective

JH Goedecke, T Olsson - Journal of Internal Medicine, 2020 - Wiley Online Library
The prevalence of type 2 diabetes (T2D) is higher in black Africans than their European
counterparts. This review summarizes the research exploring the pathogenesis of T2D in …

[HTML][HTML] Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study

M Jacques, J Kuang, DJ Bishop, X Yan… - The FASEB …, 2020 - ncbi.nlm.nih.gov
Mitochondrial respiration using the oxygraph‐2k respirometer (Oroboros) is widely used to
estimate mitochondrial capacity in human skeletal muscle. Here, we measured …

Changes in systemic and subcutaneous adipose tissue inflammation and oxidative stress in response to exercise training in obese black African women

PA Nono Nankam, AE Mendham… - The Journal of …, 2020 - Wiley Online Library
Key points Inflammation and oxidative stress are interrelated during obesity and contribute
to the development of insulin resistance; and exercise training represents a key component …