miRNAs insights into rheumatoid arthritis: Favorable and detrimental aspects of key performers

AS Doghish, A Ismail, HA El-Mahdy, SY Elkhawaga… - Life Sciences, 2023 - Elsevier
Rheumatoid arthritis (RA) is a severe autoimmune inflammation that mostly affects the joints.
It's a multifactorial disease. Its clinical picture depends on genetic and epigenetic factors …

[HTML][HTML] Inflammation and cardiovascular disease: From mechanisms to therapeutics

A Alfaddagh, SS Martin, TM Leucker, ED Michos… - American journal of …, 2020 - Elsevier
Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

T helper type (Th1/Th2) responses to SARS-CoV-2 and influenza A (H1N1) virus: From cytokines produced to immune responses

E Aleebrahim-Dehkordi, B Molavi, M Mokhtari… - Transplant …, 2022 - Elsevier
Cytokines produced by T helper cells (T h cells) have essential roles in the body's defense
against viruses. Type 1 T helper (Th1) cells are essential for the host defense toward …

Kawasaki disease: pathophysiology and insights from mouse models

M Noval Rivas, M Arditi - Nature Reviews Rheumatology, 2020 - nature.com
Kawasaki disease is an acute febrile illness and systemic vasculitis of unknown aetiology
that predominantly afflicts young children, causes coronary artery aneurysms and can result …

Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction: potential diagnostic biomarkers and therapeutic targets

MG Scioli, G Storti, F D'Amico… - Journal of Clinical …, 2020 - mdpi.com
Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

Needle-free injection of exosomes derived from human dermal fibroblast spheroids ameliorates skin photoaging

S Hu, Z Li, J Cores, K Huang, T Su, PU Dinh… - ACS nano, 2019 - ACS Publications
Human dermal fibroblasts (HDFs), the main cell population of the dermis, gradually lose
their ability to produce collagen and renew intercellular matrix with aging. One clinical …

Role of host and pathogen-derived microRNAs in immune regulation during infectious and inflammatory diseases

K Chandan, M Gupta, M Sarwat - Frontiers in immunology, 2020 - frontiersin.org
MicroRNAs (miRNAs, miRs) are short, endogenously initiated, non-coding RNAs that bind to
target mRNAs, leading to the degradation or translational suppression of respective mRNAs …

[HTML][HTML] Kawasaki disease: pathophysiology and insights from mouse models

MN Rivas, M Arditi - Nature reviews. Rheumatology, 2020 - ncbi.nlm.nih.gov
Kawasaki disease is an acute febrile illness and systemic vasculitis of unknown aetiology
that predominantly afflicts young children, causes coronary artery aneurysms and can result …

The trans-omics landscape of COVID-19

P Wu, D Chen, W Ding, P Wu, H Hou, Y Bai… - Nature …, 2021 - nature.com
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency.
Various omics results have been reported for COVID-19, but the molecular hallmarks of …