Pathophysiology of hypertension: the mosaic theory and beyond

DG Harrison, TM Coffman, CS Wilcox - Circulation research, 2021 - Am Heart Assoc
Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that
hypertension is the result of many factors that interact to raise blood pressure and cause end …

Molecular mechanisms of obesity-linked cardiac dysfunction: an up-date on current knowledge

J Gutiérrez-Cuevas, A Sandoval-Rodriguez… - Cells, 2021 - mdpi.com
Obesity is defined as excessive body fat accumulation, and worldwide obesity has nearly
tripled since 1975. Excess of free fatty acids (FFAs) and triglycerides in obese individuals …

[HTML][HTML] Physicochemical characterisation, molecular docking, and drug-likeness evaluation of hypotensive peptides encrypted in flaxseed proteome

D Ji, M Xu, CC Udenigwe, D Agyei - Current research in food science, 2020 - Elsevier
In this study, hypotensive peptides derived from mature flaxseed protein sequences were
predicted in silico using BIOPEP-UWM with nine proteases, three each from digestive, plant …

Role of the renin-angiotensin system in the development of COVID-19-associated neurological manifestations

LA Méndez-García, G Escobedo… - Frontiers in Cellular …, 2022 - frontiersin.org
SARS-CoV-2 causes COVID-19, which has claimed millions of lives. This virus can infect
various cells and tissues, including the brain, for which numerous neurological symptoms …

Renin activity in heart failure with reduced systolic function—new insights

RD Sullivan, RM Mehta, R Tripathi, GL Reed… - International Journal of …, 2019 - mdpi.com
Regardless of the cause, symptomatic heart failure (HF) with reduced ejection fraction (rEF)
is characterized by pathological activation of the renin–angiotensin–aldosterone system …

[HTML][HTML] Arctium lappa L. root extract induces cell death via mitochondrial-mediated caspase-dependent apoptosis in Jurkat human leukemic T cells

RASG Don, MKK Yap - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Arctium lappa L. is a perennial herb traditionally consumed to improve well-being. It has
been widely reported for its antioxidant properties; however, very little is known for its exact …

Decades-old renin inhibitors are still struggling to find a niche in antihypertensive therapy. A fleeting look at the old and the promising new molecules

K Ramya, R Suresh, HY Kumar, BRP Kumar… - Bioorganic & medicinal …, 2020 - Elsevier
Hypertension is a diverse illness interlinked with cerebral, cardiovascular (CVS) and renal
abnormalities. Presently, the malady is being treated by focusing on Renin-angiotensin …

Therapeutic evaluation of rutin in two-kidney one-clip model of renovascular hypertension in rat

S Kaur, A Muthuraman - Life sciences, 2016 - Elsevier
Aim The current investigation, designed to investigate the role of rutin in two-kidney one-clip
(2K1C) induced renovascular dysfunction associated with hypertension in rat. Main methods …

Repurposing of RAS-pathway mediated drugs for intestinal inflammation related diseases for treating SARS-CoV-2 infection

A Sinha, RG Vaggu, R Swain, S Patnaik - Current Microbiology, 2023 - Springer
Abstract Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is an emerging
zoonotic virus, which causes Coronavirus Disease 2019 (COVID-19). Entry of coronaviruses …

Theoretical investigation on known renin inhibitors and generation of ligand-based pharmacophore models for hypertension treatment

L Loganathan, J Sankar, K Rajendran… - Journal of …, 2024 - Taylor & Francis
The renin enzyme is considered a promising target for hypertension and renal diseases.
Over the last three decades, several experimental and theoretical studies have been …