Tamoxifen is the most widely used anti-oestrogen for the treatment of hormone-dependent
breast cancer. The pharmacological activity of tamoxifen is dependent on its conversion by …

Objective: Women taking tamoxifen for the treatment or prevention of recurrence of breast
cancer are likely to take antidepressants either for a psychiatric disorder or for hot flashes …

Abstract The International Menopause Society (IMS) has produced these new 2016
recommendations on women's midlife health and menopause hormone therapy (MHT) to …

Objective To characterise whether some selective serotonin reuptake inhibitor (SSRI)
antidepressants reduce tamoxifen's effectiveness by inhibiting its bioactivation by …

Purpose The use of cytochrome P450 2D6–inhibiting drugs (CYP2D6 inhibitors) during
tamoxifen treatment leads to a decrease in plasma concentration of endoxifen, the major …

Очередное, четвертое издание монографии, посвященной проблеме депрессий. В
книге, выполненной через 11 лет после выхода в свет в 2003 г. предыдущего издания …

Purpose Up to 75% of women experience hot flashes, which can negatively impact quality of
life. As hot flash physiology is not definitively understood, it cannot be assumed that effective …

Tamoxifen reduces the rate of breast cancer recurrence by approximately a half. Tamoxifen
is metabolized to more active metabolites by enzymes encoded by polymorphic genes …

Population-based prescription databases in Nordic countries have become a mainstay of
epidemiologic research. Denmark has both national and regional population-based …

Serotonin reuptake inhibitors (SRIs) are safe and widely used for a variety of indications
including depressive disorders, anxiety, and chronic pain. Besides inhibiting the serotonin …