Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders
VS Sohal, JLR Rubenstein - Molecular psychiatry, 2019 - nature.com
Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
An overview of autism spectrum disorder, heterogeneity and treatment options
Since the documented observations of Kanner in 1943, there has been great debate about
the diagnoses, the sub-types, and the diagnostic threshold that relates to what is now known …
the diagnoses, the sub-types, and the diagnostic threshold that relates to what is now known …
Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder
The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD)
are not well understood. Using a large neuroimaging dataset, we identified three latent …
are not well understood. Using a large neuroimaging dataset, we identified three latent …
[PDF][PDF] Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders
PF Sullivan, DH Geschwind - Cell, 2019 - cell.com
Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …
Art therapy: a complementary treatment for mental disorders
J Hu, J Zhang, L Hu, H Yu, J Xu - Frontiers in psychology, 2021 - frontiersin.org
Art therapy, as a non-pharmacological medical complementary and alternative therapy, has
been used as one of medical interventions with good clinical effects on mental disorders …
been used as one of medical interventions with good clinical effects on mental disorders …
Big data approaches to decomposing heterogeneity across the autism spectrum
Autism is a diagnostic label based on behavior. While the diagnostic criteria attempt to
maximize clinical consensus, it also masks a wide degree of heterogeneity between and …
maximize clinical consensus, it also masks a wide degree of heterogeneity between and …
Advancing the understanding of autism disease mechanisms through genetics
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …
fueled remarkable advances in our understanding of its potential neurobiological …
Deriving reproducible biomarkers from multi-site resting-state data: An Autism-based example
Abstract Resting-state functional Magnetic Resonance Imaging (R-fMRI) holds the promise
to reveal functional biomarkers of neuropsychiatric disorders. However, extracting such …
to reveal functional biomarkers of neuropsychiatric disorders. However, extracting such …
Enhancing studies of the connectome in autism using the autism brain imaging data exchange II
The second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance
the scope of brain connectomics research in Autism Spectrum Disorder (ASD). Consistent …
the scope of brain connectomics research in Autism Spectrum Disorder (ASD). Consistent …
EEG analytics for early detection of autism spectrum disorder: a data-driven approach
Autism spectrum disorder (ASD) is a complex and heterogeneous disorder, diagnosed on
the basis of behavioral symptoms during the second year of life or later. Finding scalable …
the basis of behavioral symptoms during the second year of life or later. Finding scalable …