Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers

R Campagna, V Pozzi, D Sartini, E Salvolini… - Cancers, 2021 - mdpi.com
Simple Summary Skin cancers (SC) are a frequent type of malignancy in white populations
and include malignant melanoma and non-melanoma skin cancer. Due to their increasing …

Nicotinamide N-Methyltransferase as Promising Tool for Management of Gastrointestinal Neoplasms

V Pozzi, R Campagna, D Sartini, M Emanuelli - Biomolecules, 2022 - mdpi.com
Gastrointestinal (GI) neoplasms include esophageal, gastric, colorectal, hepatic, and
pancreatic cancers. They are characterized by asymptomatic behavior, being responsible for …

[HTML][HTML] Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury

R Campagna, Ł Mateuszuk, K Wojnar-Lason… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Nicotinamide N-methyltransferase (NNMT, EC 2.1. 1.1.) plays an important role in
the growth of many different tumours and is also involved in various non-neoplastic …

Nicotinamide N -methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma …

SW Tang, TC Yang, WC Lin, WH Chang… - …, 2011 - academic.oup.com
Nicotinamide N-methyltransferase (NNMT) was recently identified as one clear cell renal cell
carcinoma (ccRCC)-associated gene by analyzing full-length complementary DNA-enriched …

Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity

Y Gao, MJ Van Haren, EE Moret… - Journal of medicinal …, 2019 - ACS Publications
Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide to form
N-methylnicotinamide. Overexpression of NNMT is associated with a variety of diseases …

Nicotinamide N‐methyltransferase gene silencing enhances chemosensitivity of melanoma cell lines

R Campagna, E Salvolini, V Pompei… - Pigment Cell & …, 2021 - Wiley Online Library
Melanoma accounts for less than 5% of all cutaneous neoplasms but is responsible for the
greater part of skin cancer–related deaths. Therefore, the identification of molecules that …

Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma

A Reustle, LS Menig, P Leuthold… - Clinical and …, 2022 - Wiley Online Library
Background The metabolic enzyme nicotinamide‐N‐methyltransferase (NNMT) is highly
expressed in various cancer entities, suggesting tumour‐promoting functions. We …

Nicotinamide N-Methyltransferase in head and neck tumors: A comprehensive review

L Togni, M Mascitti, D Sartini, R Campagna, V Pozzi… - Biomolecules, 2021 - mdpi.com
The head and neck tumors (HNT) are a heterogeneous group of diseases ranging from
benign to malignant lesions, with distinctive molecular and clinical behaviors. Several …

The Utility of Nicotinamide N-methyltransferase as a potential biomarker to predict the oncological outcomes for urological cancers: an update

R Campagna, V Pozzi, G Spinelli, D Sartini, G Milanese… - Biomolecules, 2021 - mdpi.com
Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation reaction of
nicotinamide, using S-adenosyl-L-methionine as the methyl donor. Enzyme overexpression …

Structural Basis of Substrate Recognition in Human Nicotinamide N-Methyltransferase

Y Peng, D Sartini, V Pozzi, D Wilk, M Emanuelli… - Biochemistry, 2011 - ACS Publications
Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide,
pyridines, and other analogues using S-adenosyl-l-methionine as donor. NNMT plays a …