Monocytes develop in the bone marrow and represent the primary type of mononuclear
phagocyte found in the blood. They were long thought of as a source for tissue …

Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis
of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead …

A large body of evidence indicates that chronic inflammation is one of several key risk
factors for cancer initiation, progression, and metastasis. However, the underlying …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

Dimethyl fumarate (DMF) is a first-line-treatment for relapsing-remitting multiple sclerosis
(RRMS). The redox master regulator Nrf2, essential for redox balance, is a target of DMF, but …

Abstract Interleukin (IL)-17A is expressed in the tumor microenvironment where it appears to
contribute to tumor development, but its precise role in tumor immunity remains …

Myeloid-derived suppressor cells (MDSCs) were initially identified in humans and mice with
cancer where they profoundly suppress T cell–and NK cell–mediated antitumor immunity …

The aging process is associated with chronic low-grade inflammation in both humans and
rodents, commonly called inflammaging. At the same time, there is a gradual decline in the …

Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes,
macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases …

Expansion of myeloid-derived suppressor cells (MDSCs) has been documented in some
murine models and patients with autoimmune diseases, but the exact role of MDSCs in this …