Polysaccharide-based tumor microenvironment-responsive drug delivery systems for cancer therapy

Q Wu, Y Hu, B Yu, H Hu, FJ Xu - Journal of Controlled Release, 2023 - Elsevier
The biochemical indicators of tumor microenvironment (TME) that are different from normal
tissues provide the possibility for constructing intelligent drug delivery systems (DDSs) …

Hyaluronic acid in rheumatology

H Sprott, C Fleck - Pharmaceutics, 2023 - mdpi.com
Hyaluronic acid (HA), also known as hyaluronan, is an anionic glycosaminoglycan widely
distributed throughout various tissues of the human body. It stands out from other …

CD44-targeting hyaluronic acid-selenium nanoparticles boost functional recovery following spinal cord injury

W Luo, Y Li, J Zhao, R Niu, C Xiang, M Zhang… - Journal of …, 2024 - Springer
Background Therapeutic strategies based on scavenging reactive oxygen species (ROS)
and suppressing inflammatory cascades are effective in improving functional recovery after …

[HTML][HTML] A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment

V Marotti, Y Xu, CB Michalowski, W Zhang… - Bioactive materials, 2024 - Elsevier
Current treatments for inflammatory bowel disease (IBD) treatment consist of anti-
inflammatory products. In this study, we sought to induce the physiological secretion of …

Platinum based theranostics nanoplatforms for antitumor applications

H Li, S Cheng, J Zhai, K Lei, P Zhou, K Cai… - Journal of Materials …, 2023 - pubs.rsc.org
Platinum (Pt) based nanoplatforms are biocompatible nanoagents with photothermal
antitumor performance, while exhibiting excellent radiotherapy sensitization properties. Pt …

Anti-inflammatory and antioxidant effects on skin based on supramolecular hyaluronic acid–ectoin

B Lu, S Zhao, J Zhang, J Zhan, J Zhang, Z Liu… - Journal of Materials …, 2024 - pubs.rsc.org
We addressed the damage caused by internal and external factors on the skin, as well as
the aging phenomenon caused by delayed repair after damage. We prepared …

Emerging drug delivery systems with traditional routes–A roadmap to chronic inflammatory diseases

K Min, A Sahu, SH Jeon, G Tae - Advanced Drug Delivery Reviews, 2023 - Elsevier
Inflammation is prevalent and inevitable in daily life but can generally be accommodated by
the immune systems. However, incapable self-healing and persistent inflammation can …

Stimuli responsiveness of recent biomacromolecular systems (concept to market): A review

D Singh, Y Sharma, D Dheer, R Shankar - International Journal of …, 2024 - Elsevier
Stimuli responsive delivery systems, also known as smart/intelligent drug delivery systems,
are specialized delivery vehicles designed to provide spatiotemporal control over drug …

Photothermally sensitive gold nanocage augments the antitumor efficiency of immune checkpoint blockade in immune “cold” tumors

G Xiao, Y Zhao, X Wang, C Zeng, F Luo… - Frontiers in …, 2023 - frontiersin.org
Introduction Immune checkpoint blockade (ICB) has revolutionized the therapy landscape of
malignancy melanoma. However, the clinical benefits from this regimen remain limited …

Repairing gastric ulcer with hyaluronic acid/extracellular matrix composite through promoting M2-type polarization of macrophages

R Ni, Y Luo, L Jiang, X Mao, Y Feng, S Tuersun… - International Journal of …, 2023 - Elsevier
The treatment of gastric ulcer and perforation using synthetic and biomaterials has been a
clinical challenge. In this work, a drug-carrying layer of hyaluronic acid was combined with a …