Small molecule inhibitors targeting activator protein 1 (AP-1) miniperspective

N Ye, Y Ding, C Wild, Q Shen… - Journal of medicinal …, 2014 - ACS Publications
Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of
cellular processes including proliferation, apoptosis, differentiation, survival, cell migration …

Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists

A Abdelrahman, SG Yerande, V Namasivayam… - European journal of …, 2020 - Elsevier
Adenosine acts as a powerful signaling molecule via four distinct G protein-coupled
receptors, designated A 1, A 2A, A 2B and A 3 adenosine receptors (ARs). A 2A and A 2B …

Inhibitors of hepatitis C virus polymerase

SSK Lee, W Shen, X Zheng, IC Jacobson - US Patent 8,771,665, 2014 - Google Patents
Behrens et al., Identification and properties of the RNA-dependent (21) Appl. No.:
13/328,036 Rina polymerase of hepatitis C virus. EMBO. J., 15 (1): 12-33 (1996). Biswal et …

Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers

A Giordano, KK Vasu, HM Thakar, RS Giri… - US Patent …, 2014 - Google Patents
Bruce etal (2004): STN International HCAPLUS database, Colum bus (OH), accession No.:
2004: 965245.* Takaya etal (1985): STN International HCAPLUS database, Colum bus …

Small molecules that enable cartilage rejuvenation

D Evseenko, BJ Van Handel, V John - US Patent 11,072,592, 2021 - Google Patents
2018-06-06 Assigned to REGENTS OF THE UNIVERSITY OF CALIFORNIA reassignment
REGENTS OF THE UNIVERSITY OF CALIFORNIA ASSIGNMENT OF ASSIGNORS …

Small molecules that enable cartilage rejuvenation

D Evseenko, BJ Van Handel, V John - US Patent 11,247,974, 2022 - Google Patents
2021-10-15 Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
reassignment THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ASSIGNMENT OF …

Composition and methods for cell modulation

JB Smith, V Guarcello - US Patent App. 14/385,271, 2015 - Google Patents
Composition and methods for affecting cell proliferation, metabolism or sensitization,
including the potentiation of proteasome inhibitor therapy for the treatment of disease …

Fluorinated thiazoles for use in treating cancer

JG Santano, RL Grifols, FA Palomera… - US Patent …, 2014 - Google Patents
Compounds of formula (I) or their pharmaceutically accept able salts, or their stereoisomers
or mixtures of stereoisomers, where: R is selected from the group consisting of phenyl, and …