Significance: Protein S-nitrosylation, the oxidative modification of cysteine by nitric oxide
(NO) to form protein S-nitrosothiols (SNOs), mediates redox-based signaling that conveys, in …

Neurodegenerative disorders like Alzheimer's disease and Parkinson's disease are
characterized by progressive degeneration of synapses and neurons. Accumulation of …

S-nitrosylation, a prototypic redox-based posttranslational modification, is frequently
dysregulated in disease. S-nitrosoglutathione reductase (GSNOR) regulates protein S …

It is generally recognized that hepatic fibrogenesis is an end result of increased extracellular
matrix (ECM) production from the activation and proliferation of hepatic stellate cells (HSCs) …

Mitochondria can receive, integrate, and transmit a variety of signals to shape many
biochemical activities of the cell. In the process of tumor onset and growth, mitochondria …

As an intermediate metabolite of the tricarboxylic acid cycle in mitochondria, succinate is
widely investigated for its role in metabolism. In recent years, an increasing number of …

Binding of the mitochondrial chaperone TRAP1 to client proteins shapes bioenergetic and
proteostatic adaptations of cells, but the panel of TRAP1 clients is only partially defined …

Protein S-nitrosation (SNO), a posttranslational modification (PTM) of cysteine (Cys)
residues elicited by nitric oxide (NO), regulates a wide range of protein functions. As a …

Much progress has been made in understanding the roles of the secondary coordination
sphere (SCS) in tuning redox potentials of metalloproteins. In contrast, the impact of SCS on …

Understanding protein function often necessitates characterizing the flexibility of protein
structures. However, simulating protein flexibility poses significant challenges due to the …