Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …

Hypertension is a major cardiovascular risk factor. Of the many processes involved in the
pathophysiology of hypertension, vascular damage due to oxidative stress (excess …

Atherosclerosis is a chronic progressive inflammatory process that can eventually lead to
cardiovascular disease (CVD). Despite available treatment, the prevalence of …

The association between hyperuricemia and cardiovascular disease (CVD) has been
reported and studied in the past two decades. Xanthine oxidase (XO) induced uric acid (UA) …

ShcA (Src homologous-collagen homologue), family of adapter proteins, consists of three
isoforms which integrate and transduce external stimuli to different signaling networks. ShcA …

During embryonic development, cardiomyocytes undergo differentiation and maturation,
processes that are tightly regulated by tissue-specific signaling cascades. Although redox …

It is well-established that aberrant WNT expression and signaling is associated with
developmental defects, malignant transformation and carcinogenesis. More recently, WNT …

This study aimed to examine the in vivo and in vitro therapeutic effects of glycyrrhizic acid
(GA) on steroid-induced osteonecrosis of the femoral head (SONFH), which is caused by the …

Objective—Diabetes mellitus causes vascular endothelial dysfunction and alters vascular
microRNA expression. We investigated whether endothelial microRNA-34a (miR-34a) leads …

p66Shc is a widely expressed protein that governs a variety of cardiovascular pathologies
by generating, and exacerbating, pro-apoptotic ROS signals. Here, we review p66Shc's …