Nitric oxide synthases are the major sources of nitric oxide, a critical signaling molecule
involved in a wide range of cellular and physiological processes. These enzymes comprise …

This review briefly summarizes what was known about NOS enzymology at the time of the
Nobel Prize award in 1998 and then discusses from the author's perspective some of the …

NOSs are homodimeric multidomain enzymes responsible for producing NO. In mammals,
NO acts as an intercellular messenger in a variety of signaling reactions, as well as a …

Neuronal nitric oxide synthase (nNOS) is a homodimeric cytochrome P450-like enzyme that
catalyzes the conversion of L-arginine to nitric oxide in the presence of NADPH and …

Once it was discovered that the enzyme nitric oxide synthase (NOS) is responsible for the
biosynthesis of NO, NOS became a drug target. Particularly important is the over production …

Cytochrome P450 monooxygenases (P450s) are versatile biocatalysts used in natural
products biosynthesis, xenobiotic metabolisms, and biotechnologies. In P450s, the electrons …

Abstract NAD (P) H-dependent electron-transfer (ET) systems require three functional
components: a flavin-containing NAD (P) H-dehydrogenase, one-electron carrier and metal …

Recent developments in 3-dimensional electron microcopy (3D-EM) techniques and a
concomitant drive to look at complex molecular structures, have led to a rapid increase in the …

Nitric oxide synthase (NOS) is responsible for the biosynthesis of nitric oxide (NO), an
important signaling molecule controlling diverse physiological processes such as …

The cytochrome P450 enzyme CYP102A1 from Bacillus megaterium is a highly efficient
hydroxylase of fatty acids, and there is a significant interest in using CYP102A1 for …