Pharmaceutical cocrystallization techniques. Advances and challenges
M Rodrigues, B Baptista, JA Lopes… - International Journal of …, 2018 - Elsevier
Cocrystals are homogenous (single-phase) crystalline structures composed by two or more
components in a definite stoichiometric ratio bonded together by noncovalent bonds …
components in a definite stoichiometric ratio bonded together by noncovalent bonds …
[HTML][HTML] Recent advances in improving oral drug bioavailability by cocrystals
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Introduction: Oral drug delivery is the most favored route of drug administration. However …
Introduction: Oral drug delivery is the most favored route of drug administration. However …
[HTML][HTML] Solid-state and particle size control of pharmaceutical cocrystals using atomization-based techniques
Poor bioavailability and aqueous solubility represent a major constraint during the
development of new API molecules and can influence the impact of new medicines or halt …
development of new API molecules and can influence the impact of new medicines or halt …
In-silico methods of cocrystal screening: A review on tools for rational design of pharmaceutical cocrystals
Pharmaceutical cocrystals represent a distinctive class of crystal engineered
multicomponent systems consisting an API and a crystal former non-covalently linked …
multicomponent systems consisting an API and a crystal former non-covalently linked …
Metronidazole Cocrystal Polymorphs with Gallic and Gentisic Acid Accessed through Slurry, Atomization Techniques, and Thermal Methods
In this study, key features of metronidazole (MNZ) cocrystal polymorphs with gallic acid
(GAL) and gentisic acid (GNT) were elucidated. Solvent-mediated phase transformation …
(GAL) and gentisic acid (GNT) were elucidated. Solvent-mediated phase transformation …
Nanocrystals technologies in biomedical science: bench to beside the clinic
The pharmaceutical industry is grappling with a pressing crisis in drug development,
characterized by soaring R&D costs, setbacks in blockbuster drug development due to poor …
characterized by soaring R&D costs, setbacks in blockbuster drug development due to poor …
Nanocrystal Agglomerates of Curcumin Prepared by Electrospray Drying as an Excipient‐Free Dry Powder for Inhalation
Curcumin has shown beneficial effects on pulmonary diseases with chronic inflammation or
abnormal inflammatory responses, including chronic obstructive pulmonary disease …
abnormal inflammatory responses, including chronic obstructive pulmonary disease …
Discovery of new cocrystals beyond serendipity: lessons learned from successes and failures
The past decade has witnessed remarkable progress in cocrystal research, by virtue of the
desires to address problematic properties of drugs. Notwithstanding the rapid advancements …
desires to address problematic properties of drugs. Notwithstanding the rapid advancements …
Switch between cocrystal and coamorphous forms depending on thermal modulation of hot-melt extrusion
P Shen, C Zhang, E Hu, Y Gao, Y Wei… - Molecular …, 2023 - ACS Publications
Cocrystal (CC) and coamorphous (CM) techniques have become green technologies to
improve the solubility and bioavailability of water-soluble drugs. In this study, hot-melt …
improve the solubility and bioavailability of water-soluble drugs. In this study, hot-melt …
Pharmaceutical cocrystals: Unlocking the potential of challenging drug candidates
J Pantwalawalkar, N Kale, S Nangare, S Patil… - Journal of Drug Delivery …, 2024 - Elsevier
Pharmaceutical development is often limited by drugs with unfavorable physicochemical
properties, such as poor solubility, limited permeability, and low bioavailability, which …
properties, such as poor solubility, limited permeability, and low bioavailability, which …